Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice

被引:4
|
作者
Ikaga, Reina [1 ]
Li, Dongyang [1 ,2 ]
Yamazaki, Tomomi [1 ]
机构
[1] Natl Inst Biomed Innovat Hlth & Nutr, Dept Nutr Sci, Natl Inst Hlth & Nutr, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628636, Japan
[2] Ochanomizu Univ, Grad Sch Human & Sci, Bunkyo Ku, 2-1-1 Otsuka, Tokyo 1128610, Japan
关键词
beta-Conglycinin; Ethanol-induced fatty liver; Ethanol administration; PPAR gamma; SCD1; ELEMENT-BINDING PROTEINS; INDUCED HEPATIC STEATOSIS; GENE-EXPRESSION; PROTECTS MICE; PPAR-GAMMA; CHOLESTEROL; ALCOHOL; DISEASE; INHIBITION; METABOLISM;
D O I
10.1016/j.bbrc.2017.08.155
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alcoholic fatty liver is the earliest stage of alcohol-induced liver disease leading to liver cirrhosis. beta-Conglycinin, one of the soy proteins, is known to prevent non-alcoholic fatty liver, hyperlipidemia and obesity. Therefore, we examined whether beta-conglycinin feeding has an effect on the prevention of acute ethanol-induced fatty liver in mice. Male C57BL/6J mice were fed with 20 energy% beta-conglycinin or casein for 4 weeks prior to ethanol administration and were then given ethanol or glucose, as a control, by gavage. Ethanol significantly increased liver triglyceride (TG) in mice fed casein due to the activation of peroxisome proliferator-activated receptor (PPAR) gamma 2, a nuclear transcription factor known for regulating lipid metabolism and de novo lipogenesis. The liver TG of ethanol-administered beta-conglycinin-fed mice was significantly lower than that in those fed casein, although ethanol increased the amount of liver TG in mice fed beta-conglycinin. The increased levels of PPAR gamma 2 protein and its target gene CD36 in response to an ethanol were not observed in mice fed beta-conglycinin. Moreover, beta-conglycinin decreased the basal expression of de novo lipogenesis-related genes such as stearoyl-CoA desaturase-1, and therefore, the expressions of these genes were lower in the ethanol-administered beta-conglycinin-fed mice than in the casein-fed mice. In conclusion, beta-conglycinin supplementation appears to prevent the development of fatty liver in mice caused by ethanol consumption via the suppression of alcohol induced activation of PPAR gamma 2 and the downregulation of the basal expression of de novo lipogenesis. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:542 / 547
页数:6
相关论文
共 50 条
  • [1] Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice
    Wada, Satoshi
    Yamazaki, Tomomi
    Kawano, Yukari
    Miura, Shinji
    Ezaki, Osamu
    JOURNAL OF HEPATOLOGY, 2008, 49 (03) : 441 - 450
  • [2] Herbal SGR Formula Prevents Acute Ethanol-Induced Liver Steatosis via Inhibition of Lipogenesis and Enhancement Fatty Acid Oxidation in Mice
    Qiu, Ping
    Li, Xiang
    Kong, De-song
    Li, Huan-zhou
    Niu, Cong-cong
    Pan, Su-hua
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 2015
  • [3] Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ
    Li, Dongyang
    Ikaga, Reina
    Yamazaki, Tomomi
    BRITISH JOURNAL OF NUTRITION, 2018, 119 (11) : 1220 - 1232
  • [4] Protective effects of Gymnaster koraiensis extract on ethanol-induced fatty liver in rats
    Choe, Soo Young
    Seo, Yoonhee
    Bang, Chae Young
    Woo, Seok Hoon
    Kang, Moonkyu
    ADVANCES IN TRADITIONAL MEDICINE, 2020, 20 (03) : 461 - 469
  • [5] Emodin Ameliorates Ethanol-Induced Fatty Liver Injury in Mice
    Liu, Ying
    Chen, Xiaolan
    Qiu, Mochang
    Chen, Weiqiang
    Zeng, Zhi
    Chen, Yinghua
    PHARMACOLOGY, 2014, 94 (1-2) : 71 - 77
  • [6] Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanol-induced liver steatosis in mice
    Xiong, Yu
    Yang, Yuqing
    Yang, Jin
    Chai, Hongyan
    Li, Ying
    Yang, Jing
    Jia, Ziming
    Wang, Zhengrong
    TOXICOLOGY, 2010, 276 (01) : 64 - 72
  • [7] Dietary fructose augments ethanol-induced liver pathology
    Thomes, Paul G.
    Benbow, Jennifer H.
    Brandon-Warner, Elizabeth
    Thompson, Kyle J.
    Jacobs, Carl
    Donohue, Terrence M., Jr.
    Schrum, Laura W.
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2017, 43 : 141 - 150
  • [8] Dietary β-conglycinin prevents fatty liver induced by a high-fat diet by a decrease in peroxisome proliferator-activated receptor γ2 protein
    Yamazaki, Tomomi
    Kishimoto, Kyoko
    Miura, Shinji
    Ezaki, Osamu
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2012, 23 (02) : 123 - 132
  • [9] Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver
    Jinyao Liu
    World Journal of Gastroenterology, 2014, (40) : 14672 - 14685
  • [10] Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver
    Liu, Jinyao
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (40) : 14672 - 14685