Long-term quality of life after preoperative radiochemotherapy in patients with localized and locally advanced breast cancer

被引：10

作者：

Haussmann, Jan ^{[1
]}

Nestle-Kraemling, Carolin ^{[2
]}

Boelke, Edwin ^{[1
]}

Wollandt, Sylvia ^{[3
]}

Speer, Vanessa ^{[1
]}

Njanang, Freddy-Joel ^{[1
]}

Tamaskovics, Balint ^{[1
]}

Gerber, Peter Arne ^{[4
]}

Orth, Klaus ^{[5
]}

Ruckhaeberle, Eugen ^{[8
]}

Fehm, Tanja ^{[8
]}

Corradini, Stefanie ^{[9
,10
]}

Lammering, Guido ^{[10
]}

Mohrmann, Svjetlana ^{[8
]}

Audretsch, Werner ^{[6
]}

Maas, Kitti ^{[1
]}

Roth, Stephan ^{[1
]}

Kammers, Kai ^{[7
]}

Budach, Wilfried ^{[1
]}

Matuschek, Christiane ^{[1
]}

机构：

[1] Heinrich Heine Univ, Med Fac, Dept Radiat Oncol, Dusseldorf, Germany

[2] Heinrich Heine Univ, Dept Gynecol & Obstet, EVK Dusseldorf, Dusseldorf, Germany

[3] Sana Kliniken Dusseldorf, Dept Senol, Dusseldorf, Germany

[4] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Dermatol, Dusseldorf, Germany

[5] Harzkliniken Goslar, Dept Gen Visceral & Thorac Surg, Goslar, Germany

[6] Marienhospital Dusseldorf, Dept Senol & Breast Surg, Dusseldorf, Germany

[7] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Dept Oncol,Div Biostat & Bioinformat, Baltimore, MD USA

[8] Heinrich Heine Univ Dusseldorf, Dept Gynecol, Dusseldorf, Germany

[9] LMU Univ Munich, Dept Radiat Oncol, Munich, Germany

[10] Radiotherapy Inst Bergisch Gladbach, Gladbach, Germany

来源：

STRAHLENTHERAPIE UND ONKOLOGIE | 2020年 / 196卷 / 04期

关键词：

Neoadjuvant radiochemotherapy; Cosmetic outcome; Questionnaire; Restrospective study; Evaluation; REGIONAL NODAL IRRADIATION; ADJUVANT RADIATION-THERAPY; NEOADJUVANT; RADIOTHERAPY; MASTECTOMY; SURGERY; CHEMORADIATION; CAPECITABINE; CONSERVATION; SURVIVORS;

D O I：

10.1007/s00066-019-01557-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Preoperative radiotherapy (PRT) or radiochemotherapy (PRCT) is used in different tumor sites. The aim of the study was to examine the long-term quality of life (QoL) of localized / locally advanced breast cancer patients treated with PRT/PRCT followed by breast-conserving surgery (BCS) or mastectomy (ME). Methods Assessment of QoL was done using EORTC QLQ-C30 questionnaires for overall QoL and EORTC QLQ-BR23 for breast-specific QoL. The summary scores were categorized into 4 distinct groups to classify the results. Furthermore, a comparative analysis was performed between the study cohort and a previously published reference cohort of healthy adults. We assessed the impact of different clinical, prognostic, and treatment-related factors on selected items from C30 and BR23 using a dependence analysis. Results Out of 315 patients treated with PRT/PCRT in the years 1991 to 1999, 203 patients were alive at long-term follow-up after a mean of 17.7 years (range 14-21). 37 patients were lost to follow-up and 61 patients refused to be contacted, leading to 105 patients (64 patients after BCS and 41 after ME) being willing to undergo further clinical assessment regarding QoL outcome. Overall, QoL (QLQ-C30) was rated "excellent" or "good" in 85% (mean value) of all patients (BCS 83%, ME 88%). Comparative analysis between the study cohort and a published healthy control group revealed significantly better global health status and physical and role functioning scores in the PRT/PRCT group. The analysis demonstrates no differences in nausea/vomiting, dyspnea, insomnia, constipation, or financial difficulties. According to the dependence analysis, global QoL was associated with age, operation type and ME reconstruction. Conclusion We did not detect any inferiority of PRT/PRCT compared to a healthy reference group with no hints of a detrimental long-term effect on general and breast-specific quality of life.

引用

页码：386 / 397

页数：12

共 38 条

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