Lower vitamin D levels in the breast milk is associated with atopic dermatitis in early infancy

被引:20
作者
Wang, Li-Chieh [1 ]
Chiang, Bor-Luen [2 ]
Huang, Yen-Ming [1 ]
Shen, Pei-Ting [3 ]
Huang, Hsun-Yi [3 ]
Lin, Bi-Fong [3 ]
机构
[1] Natl Taiwan Univ Hosp, Dept Pediat, 7 Chung Shan South Rd, Taipei 10002, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan
[3] Natl Taiwan Univ, Coll Life Sci, Dept Biochem Sci & Technol, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan
关键词
atopic dermatitis; breast milk; objective SCORing Atopic Dermatitis; vitamin D; D SUPPLEMENTATION; FOOD ALLERGY; DISEASE; SEVERITY; CHILDREN; ASTHMA; TRIAL;
D O I
10.1111/pai.13179
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background Our previous study showed that the discontinuation of breastfeeding could improve atopic dermatitis (AD) symptoms in exclusively breastfed infants. As vitamins A and D are influential on the immune system, we aimed to analyze the association of vitamin A and D levels in breast milk (BM) with AD. Methods We enrolled two- to four-month-old exclusively breastfed infants. The objective SCORing Atopic Dermatitis (objSCORAD) was evaluated. The lipid layer of BM was extracted and analyzed by liquid chromatography for vitamin A and D levels. Medical charts were reviewed for the clinical course of AD. Results Forty-five AD patients and 45 healthy controls were enrolled. The objSCORAD was 20.54 +/- 1.73 (shown as mean +/- SEM) in the AD group. The sex, parental atopy history, nutrient intake of mothers, and vitamin A levels in BM were not significantly different between the two groups. The 25-(OH) D-3 level in BM was significantly lower in the AD group than in the control group (1.72 +/- 0.30 and 3.95 +/- 0.64 ng/mL, respectively; P = .001). The 25-(OH) D-3 level negatively correlated with objSCORAD (P = .003). The only factor that is significantly associated with persistent AD is the objSCORAD in infancy (P = .003) after adjusting for age, sex, parental atopy history, and 25-(OH) D-3 level by multiple regression. Conclusion Vitamin D levels in BM for exclusively breastfed infants were negatively associated with objSCORAD. Lower vitamin D levels in BM might be a risk factor for infantile AD.
引用
收藏
页码:258 / 264
页数:7
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