Protein-protein interaction map is a key gateway into liver regeneration

被引:2
作者
Xie, Chao [1 ,2 ]
Gao, Jin [3 ]
Zhu, Run-Zhi [1 ]
Yuan, Yun-Sheng [1 ]
He, Hong-Lin [1 ]
Huang, Qiu-Shi [2 ]
Han, Wei [3 ]
Yu, Yan [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Municipal Key Lab Vet Biotechnol, Shanghai 200240, Peoples R China
[2] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA
[3] Shanghai Jiao Tong Univ, Sch Pharm, Lab Regener, Shanghai 200240, Peoples R China
关键词
Liver regeneration; Protein-protein interaction; Protein-protein interaction maps; Transforming growth factor beta; INTERACTION NETWORK; SYSTEM; CELL; YEAST;
D O I
10.3748/wjg.v16.i28.3491
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Recent studies indicate that the process of liver regeneration involves multiple signaling pathways and a variety of genes, cytokines and growth factors. Protein-protein interactions (PPIs) play a role in nearly all events that take place within the cell and PPI maps should be helpful in further understanding the process of liver regeneration. In this review, we discuss recent progress in understanding the PPIs that occur during liver regeneration especially those in the transforming growth factor beta signaling pathways. We believe the use of large-scale PPI maps for integrating the information already known about the liver regeneration is a useful approach in understanding liver regeneration from the standpoint of systems biology. (C) 2010 Baishideng. All rights reserved.
引用
收藏
页码:3491 / 3498
页数:8
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