Optical responses to micro-application of GABA agonists in the embryonic chick brain stem

被引：6

作者：

Sato, K

Mochida, H

Sasaki, S

Yazawa, I

Kamino, K

Momose-Sato, Y ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Grad Sch, Dept Neurobehav Med, Bunkyo Ku, Tokyo 1138519, Japan

[3] Tokyo Med & Dent Univ, Fac Med, Bunkyo Ku, Tokyo 1138519, Japan

[4] JAIC, Coll Med Care & Welf Technol, Koriyama, Fukushima 9638834, Japan

来源：

NEUROREPORT | 2001年 / 12卷 / 01期

关键词：

baclofen; chick embryo; brain stem; GABA; muscimol; novel GABA response; nucleus tractus solitarius;

D O I：

10.1097/00001756-200101220-00026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated optical responses induced by micro-application of muscimol and baclofen in the embryonic chick brain stem. Muscimol evoked biphasic optical signals which were similar to those induced by GABA. The first component was a dye-dependent absorption change that reflected membrane depolarization, and the second component was an intrinsic optical change coupled with changes in the membrane potential. On the other hand, baclofen did not elicit any optical change. The optical responses induced by muscimol persisted in the presence of picrotoxin and 2-hydroxysaclofen, suggesting that they contain a component which is not mediated by classical GABA receptors. NeuroReport 12:95-98 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：95 / 98

页数：4

共 15 条

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