Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis

被引：13
|
作者：
Hurst, Rebecca L. [1 ]
Gooch, Clifton L. [1 ,2 ]
机构：
[1] Univ S Florida, Morsani Coll Med, Dept Neurol, 2 Tampa Gen Circle 6th Floor,Room 6091, Tampa, FL 33606 USA
[2] Univ S Florida, Morsani Coll Med, Dept Neurol, 12901 Bruce B Downs Blvd MDC 55, Tampa, FL 33612 USA
来源：
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2016年 / 16卷 / 07期
关键词：
Myasthenia gravis; Muscle-specific receptor tyrosine kinase; Acetylcholine receptor antibody; Neuromuscular junction; ACETYLCHOLINE-RECEPTOR; ANTIBODIES; MG; AUTOANTIBODIES;
D O I：
10.1007/s11910-016-0668-z
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Autoimmune myasthenia gravis (MG) is the prototypic, antibody-mediated neuromuscular disease and is characterized by a decrease in the number of functional acetylcholine receptors (AChR) within the muscle end plate zone of the neuromuscular junction (NMJ). Although the pathophysiology of AChR-mediated myasthenia gravis has been extensively studied over the last 40 years since its original description by Patrick and Lindstrom(Science 180: 871-872, 1973), less is known about the much more recently described muscle-specific kinase (MuSK) antibody-mediated MG. MuSK-MG has features clinically distinct from Ach-R MG, as well as a different pattern of response to treatment and a unique immunopathogenesis.
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页数：4
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