Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions

被引：5

作者：

Zhang, Xinfu ^{[1
,2
]}

An, Xinmin ^{[2
]}

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] Beijing Forestry Univ, Coll Biol Sci & Technol, Beijing Adv Innovat Ctr Tree Breeding Mol Design, Natl Engn Res Ctr Tree Breeding & Ecol Remediat, Beijing, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

CRISPR-Cas system; type III; adaptation; ssDNA secondary structure; reverse transcriptase; ROLLING-CIRCLE REPLICATION; SPACER ACQUISITION; STRUCTURAL BASIS; EVOLUTIONARY CLASSIFICATION; IMMUNE-SYSTEM; RNA CLEAVAGE; FOREIGN DNA; HOST FACTOR; INTEGRATION; DEFENSE;

D O I：

10.3389/fmicb.2022.876174

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CRISPR-Cas systems acquire heritable defense memory against invading nucleic acids through adaptation. Type III CRISPR-Cas systems have unique and intriguing features of defense and are important in method development for Genetics research. We started to understand the common and unique properties of type III CRISPR-Cas adaptation in recent years. This review summarizes our knowledge regarding CRISPR-Cas adaptation with the emphasis on type III systems and discusses open questions for type III adaptation studies.

引用

页数：9

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