Prognostic impact of perineural invasion and lymphovascular invasion in advanced stage oral squamous cell carcinoma

被引：107

作者：

Jardim, J. F. ^{[1
]}

Francisco, A. L. N. ^{[2
,3
]}

Gondak, R. ^{[4
]}

Damascena, A. ^{[5
]}

Kowalski, L. P. ^{[2
,3
]}

机构：

[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Sao Paulo, Brazil

[2] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509900 Sao Paulo, Brazil

[3] Natl Inst Sci & Technol Oncogenom INCITO, Sao Paulo, Brazil

[4] Univ Fed Santa Catarina, Dept Pathol, BR-88040900 Florianopolis, SC, Brazil

[5] AC Camargo Canc Ctr, Int Ctr Canc Res CIPE, BR-01509900 Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2015年 / 44卷 / 01期

关键词：

squamous cell carcinoma; oral cancer; perineural invasion; vascular invasion; prognosis; survival; LYMPH-NODE METASTASIS; RADICAL SURGERY; CANCER; SURVIVAL; RECURRENCE; NECK; FEATURES; CAVITY; HEAD; TOOL;

D O I：

10.1016/j.ijom.2014.10.006

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Perineural invasion (PNI) and lymphovascular invasion (LVI) have been associated with the risk of local recurrences and lymph node metastasis. The aim of this study was to evaluate the prognostic impact of PM and LVI in patients with advanced stage squamous cell carcinoma of the tongue and floor of the mouth. One hundred and forty-two patients without previous treatment were selected. These patients underwent radical surgery with neck dissection and adjuvant treatment. Clinicopathological data were retrieved from the medical charts, including histopathology and surgery reports. Univariate analysis was performed to assess the impact of studied variables on survival. Overall survival was negatively influenced by six tumour-related factors: increasing T stage (P = 0.003), more than two clinically positive nodes (P = 0.002), extracapsular spread of lymph node metastasis (P < 0.001), tumour thickness (P = 0.04), PNI (P < 0.001), and LVI (P = 0.012). Disease-free survival was influenced by PNI (P = 0.04), extracapsular spread of lymph node metastasis (P = 0.008), and N stage (P = 0.006). Multivariate analysis showed PNI to be an independent predictor for overall survival (P = 0.01) and disease-free survival (P = 0.03). Thus the presence of PNI in oral carcinoma surgical specimens has a significant impact on survival outcomes in patients with advanced stage tumours submitted to radical surgery and adjuvant radiotherapy/radiochemotherapy.

引用

页码：23 / 28

页数：6

共 26 条

[21] The prognostic implications of the surgical margin in oral squamous cell carcinoma [J].

Sutton, DN ;

Brown, JS ;

Rogers, SN ;

Vaughan, ED ;

Woolgar, JA .

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2003, 32 (01) :30-34

[22] Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer [J].

Woo, CS ;

Silberman, H ;

Nakamura, SK ;

Ye, W ;

Sposto, R ;

Colburn, W ;

Waisman, JR ;

Silverstein, MJ .

AMERICAN JOURNAL OF SURGERY, 2002, 184 (04) :337-340

[23] Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection [J].

Woolgar, JA ;

Rogers, S ;

West, CR ;

Errington, RD ;

Brown, JS ;

Vaughan, ED .

ORAL ONCOLOGY, 1999, 35 (03) :257-265

[24] Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread [J].

Woolgar, JA ;

Rogers, SN ;

Lowe, D ;

Brown, JS ;

Vaughan, ED .

ORAL ONCOLOGY, 2003, 39 (02) :130-137

[25] Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma [J].

Woolgar, JA .

ORAL ONCOLOGY, 2006, 42 (03) :229-239

[26] Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma [J].

Yanamoto, S. ;

Yamada, S. ;

Takahashi, H. ;

Yoshitomi, I. ;

Kawasaki, G. ;

Ikeda, H. ;

Minamizato, T. ;

Shiraishi, T. ;

Fujita, S. ;

Ikeda, T. ;

Asahina, I. ;

Umeda, M. .

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2012, 41 (10) :1195-1200

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