Hepatitis B virus infection and coronary atherosclerosis: Results from a population with relatively high prevalence of hepatitis B virus

被引：37

作者：

Tong, De-Yan ^{[1
]}

Wang, Xiao-Hua ^{[1
]}

Xu, Cong-Feng ^{[2
]}

Yang, Ying-Zhen ^{[2
]}

Xiong, Si-Dong ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Dept Immunol, Ctr Gene Immunizat & Vaccine Res Shanghai, Shanghai 200032, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 09期

基金：

国家高技术研究发展计划(863计划);

关键词：

Coronary artery disease; Hepatitis B virus; C-reactive protein; Infection;

D O I：

10.3748/wjg.v11.i9.1292

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To investigate the possible association between hepatitis B virus (HBV) infection and angiographically proven coronary artery disease (CAD) in a population with relatively high prevalence of HBV. METHODS: Sera from 434 patients who underwent coronary angiography were tested for HBV antigens (HBsAg, HBeAg) and antibodies (Anti-HBs, Anti-HBc and Anti-HBe) by ELISA. RESULTS: Seventy-seven percent (224/291) of the patients with CAD and 73.4% (105/143) of the patients without angiographic evidence of atherosclerosis were seropositive for HBV (P > 0.05). However, C-reactive protein (CRP) levels were significantly higher in patients with CAD (P = 0.008), while lower in HBV seropositive population (P = 0.043 and P = 0.021 after adjustment for conventional risk factors). CONCLUSION: Our results suggested HBV infection negatively correlates with CRP levels, but seems not to be associated with coronary atherosclerosis. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：1292 / 1296

页数：5

共 36 条

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