Highly efficient synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reactions in water

被引：29
作者：
Lin, Hua [1 ]
Sun, Xing-Wen [1 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 36期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.tetlet.2008.06.055
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids in pure water has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in good to excellent yields. (C) 2008 Elsevier Ltd. All rights reserved.
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页码：5343 / 5346
页数：4
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