Class 3 semaphorins and their receptors in physiological and pathological angiogenesis

被引：27
作者：
Staton, Carolyn A. [1 ]
机构：
[1] Univ Sheffield, Fac Med Dent & Hlth, Acad Unit Surg Oncol, Microcirculat Res Grp, Sheffield S10 2RX, S Yorkshire, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷
关键词：
angiogenesis; class; 3; semaphorin; neuropilin; plexin; vascular endothelial growth factor (VEGF); ENDOTHELIAL GROWTH-FACTOR; DIFFERENTIAL EXPRESSION; HORMONAL-REGULATION; PLEXIN D1; NEUROPILIN-1; CELLS; VEGF; LUNG; CANCER; GENES;
D O I：
10.1042/BST20110654
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Class 3 semaphorins (Sema3) are a family of secreted proteins that were originally identified as axon guidance factors mediating their signal transduction by forming complexes with neuropilins and plexins. However, the wide expression pattern of Sema3 suggested additional functions other than those associated with the nervous system, and indeed many studies have now indicated that Sema3 proteins and their receptors play a role in angiogenesis. The present review specifically focuses on recent evidence for this role in both physiological and pathological angiogenesis.
引用
收藏
页码：1565 / 1570
页数：6
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