Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome

被引：136
作者：
Eisensehr, I
Wetter, TC
Linke, R
Noachtar, S
Von Lindeiner, H
Gildehaus, FJ
Trenkwalder, C
Tatsch, K
机构：
[1] Univ Munich, Dept Neurol, D-8000 Munich, Germany
[2] Univ Munich, Dept Nucl Med, D-8000 Munich, Germany
[3] Max Planck Inst Psychiat, Munich, Germany
[4] Univ Gottingen, Dept Neurophysiol, D-3400 Gottingen, Germany
来源：
NEUROLOGY | 2001年 / 57卷 / 07期
关键词：
D O I：
10.1212/WNL.57.7.1307
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fourteen drug-naive and 11 levodopa-treated patients with idiopathic restless legs syndrome (RLS), and 10 controls age-matched to each RLS group separately were examined with polysomnography (PSG), [I-123]-(N)-(3-iodopropen-2-yl)-2 beta -carbomethoxy-3 beta-(4-chlorophenyl) tropane (I-123-IPT) SPECT, and [I-123]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide (I-123-IBZM) SPECT. Drug-naive and levodopa-treated patients with RLS and controls showed similar striatal dopamine transporter and dopamine D-2-receptor binding, the latter declining with age. The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS.
引用
收藏
页码：1307 / 1309
页数：3
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