Asymmetric synthesis of hydroxyphosphonates

被引:187
作者
Kolodiazhnyi, OI [1 ]
机构
[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrol Chem, UA-02094 Kiev, Ukraine
关键词
D O I
10.1016/j.tetasy.2005.09.007
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Hydroxyphosphonates have attracted considerable attention as biologically active compounds, enzyme inhibitors, and drugs. Over the last few years significant interest in the asymmetric synthesis and practical application of chiral hydroxyphosphonates has been reported, which shows the theoretical interest and the practical importance of hydroxyphosphonates. Ail overview of recent synthetic approaches to chiral hydroxyphosphonates and determinations of their absolute configuration is presented. Data oil the practical applications of hydroxyphosphonates are also discussed. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3295 / 3340
页数:46
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