Translational neurobiology in Shank mutant mice - Model systems for neuropsychiatric disorders

被引：38

作者：

Schmeisser, Michael J. ^{[1
]}

机构：

[1] Univ Ulm, Inst Anat & Cell Biol, D-89081 Ulm, Germany

来源：

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2015年 / 200卷

关键词：

Synapse; Shank1; Shank2; Shank3; Autism; ASD; Schizophrenia; POSTSYNAPTIC DENSITY; BINDING-PROTEIN; EMERGING ROLE; GENE; AUTISM; BEHAVIORS; MUTATIONS; ISOFORMS; FAMILY;

D O I：

10.1016/j.aanat.2015.03.006

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The Shank family comprises three core postsynaptic scaffold proteins of excitatory synapses in the mammalian brain: Shank1, Shank2 and Shank3. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems. Besides intriguing alterations in behavior, dysfunction of glutamatergic synapses has emerged as a pathological hallmark among several Shank mutant lines. However, there is very limited knowledge of the underlying pathomechanisms. Therefore, precise neurobiological evaluation of morphological, molecular and electrophysiological phenotypes in Shank mutants is crucially needed. In this brief review, I will focus on the Shank mutant mouse lines we have generated so far and discuss how they might help us to develop translational treatment studies in the future. (C) 2015 Elsevier GmbH. All rights reserved.

引用

页码：115 / 117

页数：3

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