Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

被引:145
作者
Melino, G. [1 ,2 ]
Gallagher, E. [3 ]
Aqeilan, R. I. [4 ]
Knight, R. [2 ]
Peschiaroli, A. [1 ]
Rossi, M. [2 ]
Scialpi, F. [1 ]
Malatesta, M. [1 ]
Zocchi, L. [1 ]
Browne, G. [2 ]
Ciechanover, A. [5 ]
Bernassola, F. [1 ]
机构
[1] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, IDI IRCCS Biochem Lab, I-00133 Rome, Italy
[2] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England
[3] UCL Royal Free & Univ Coll Med Sch, London W1T 4JF, England
[4] Ohio State Univ, Columbus, OH 43210 USA
[5] Technion Israel Inst Technol, Canc & Vasc Biol Ctr, Rappaport Fac Med & Res Inst, IL-31096 Haifa, Israel
基金
英国医学研究理事会;
关键词
ubiquitin E3 ligase; apoptosis; JunB; p53 family members; Notch;
D O I
10.1038/cdd.2008.60
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.
引用
收藏
页码:1103 / 1112
页数:10
相关论文
共 63 条
  • [21] Itch inhibition regulates chemosensitivity in vitro
    Hansen, T. M.
    Rossi, M.
    Roperch, J. P.
    Ansell, K.
    Simpson, K.
    Taylor, D.
    Mathon, N.
    Knight, R. A.
    Melino, G.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (01) : 33 - 36
  • [22] Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB
    Hartenstein, B
    Teurich, S
    Hess, J
    Schenkel, J
    Schorpp-Kistner, M
    Angel, P
    [J]. EMBO JOURNAL, 2002, 21 (23) : 6321 - 6329
  • [23] N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel golgi-associated protein
    Harvey, KF
    Shearwin-Whyatt, LM
    Fotia, A
    Parton, RG
    Kumar, S
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) : 9307 - 9317
  • [24] Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    Heissmeyer, V
    Macián, F
    Im, SH
    Varma, R
    Feske, S
    Venuprasad, K
    Gu, H
    Liu, YC
    Dustin, ML
    Rao, A
    [J]. NATURE IMMUNOLOGY, 2004, 5 (03) : 255 - 265
  • [25] Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel
    Henry, PC
    Kanelis, V
    O'Brien, MC
    Kim, B
    Gautschi, I
    Forman-Kay, J
    Schild, L
    Rotin, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (22) : 20019 - 20028
  • [26] Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins
    Hettema, EH
    Valdez-Taubas, J
    Pelham, HRB
    [J]. EMBO JOURNAL, 2004, 23 (06) : 1279 - 1288
  • [27] A FAMILY OF PROTEINS STRUCTURALLY AND FUNCTIONALLY RELATED TO THE E6-AP UBIQUITIN-PROTEIN LIGASE (VOL 92, PG 2563, 1995)
    HUIBREGTSE, JM
    SCHEFFNER, M
    BEAUDENON, S
    HOWLEY, PM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) : 5249 - 5249
  • [28] Role for the p53 homologue p73 in E2F-1-induced apoptosis
    Irwin, M
    Marin, MC
    Phillips, AC
    Seelan, RS
    Smith, DI
    Liu, WG
    Flores, ER
    Tsai, KY
    Jacks, T
    Vousden, KH
    Kaelin, WG
    [J]. NATURE, 2000, 407 (6804) : 645 - 648
  • [29] Chemosensitivity linked to p73 function
    Irwin, MS
    Kondo, K
    Marin, MC
    Cheng, LS
    Hahn, WC
    Kaelin, WG
    [J]. CANCER CELL, 2003, 3 (04) : 403 - 410
  • [30] The thymus and T-cell commitment: the right niche for Notch?
    Jenkinson, EJ
    Jenkinson, WE
    Rossi, SW
    Anderson, G
    [J]. NATURE REVIEWS IMMUNOLOGY, 2006, 6 (07) : 551 - 555