Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease

被引：27

作者：

Hamburg, Naomi M. ^{[1
]}

Leeper, Nicholas J. ^{[2
,3
]}

机构：

[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[2] Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Div Vasc Surg, Stanford, CA 94305 USA

来源：

CURRENT VASCULAR PHARMACOLOGY | 2015年 / 13卷 / 03期

关键词：

Biomarker; peripheral arterial disease; epigenetics; EMBRYONIC STEM-CELLS; SMOOTH-MUSCLE-CELLS; CIRCULATING MICRORNAS; SKELETAL-MUSCLE; ENDOTHELIAL DYSFUNCTION; IN-VIVO; CARDIOVASCULAR-DISEASE; MITOCHONDRIAL DYNAMICS; VASCULAR ENDOTHELIUM; FUNCTIONAL-CAPACITY;

D O I：

10.2174/15701611113119990014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peripheral artery disease (PAD) produces significant disability attributable to lower extremity ischemia. Limited treatment modalities exist to ameliorate clinical symptoms in patients with PAD. Growing evidence links microRNAs to key processes that govern disease expression in PAD including angiogenesis, endothelial function, inflammation, vascular regeneration, vascular smooth muscle cell function, restenosis, and mitochondrial function. MicroRNAs have been identified in circulation and may serve as novel biomarkers in PAD. This article reviews the potential contribution of microRNA to key pathways of disease development in PAD that may lead to microRNA-based diagnostic and therapeutic approaches.

引用

页码：316 / 323

页数：8

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