Myocarditis of mixed connective tissue disease: Favourable outcome after intravenous pulsed cyclophosphamide

被引：13

作者：

Hammann, C ^{[1
]}

Genton, CY ^{[1
]}

Delabays, A ^{[1
]}

Delaloye, AB ^{[1
]}

Bogousslavsky, J ^{[1
]}

Spertini, F ^{[1
]}

机构：

[1] CHU Vaudois, Dept Med, Div Immunol & Allergy, CH-1011 Lausanne, Switzerland

来源：

CLINICAL RHEUMATOLOGY | 1999年 / 18卷 / 01期

关键词：

cyclophosphamide; heart failure; mixed connective tissue disease; myocarditis;

D O I：

10.1007/s100670050062

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke's aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55% and remained stable 17 months thereafter.

引用

页码：85 / 87

页数：3

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