Synthesis of Pyrroles through Rhodium(III)-Catalyzed Reactions of Allylamines and Alkenes

被引：37

作者：

Kim, Dong-Su ^{[1
]}

Seo, Yong-Sik ^{[1
]}

Jun, Chul-Ho ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 15期

基金：

新加坡国家研究基金会;

关键词：

C-H ACTIVATION; NATURAL-PRODUCTS; N-ANNULATION; CATALYZED REACTIONS; COUPLING REACTIONS; ORGANIC-SYNTHESIS; BOND FORMATION; ALKYNES; BENZYLAMINES; LAMELLARINS;

D O I：

10.1021/acs.orglett.5b01811

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrrole derivatives are generated in reactions of allylamines with alkenes that are promoted by a Rh(III) catalyst in the presence of AgOAc. This process, which involves chelation assisted C-H bond activation and N-annulation, is applied to a three step synthesis of Zomepirac.

引用

收藏

页码：3842 / 3845

页数：4

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