The dynamic interplay between osteoclasts and the immune system

被引：61

作者：

Nakashima, Tomoki ^{[1
]}

Takayanagi, Hiroshi ^{[1
,2
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Cell Signaling, Grad Sch, Bunkyo Ku, Tokyo 1138549, Japan

[2] Tokyo Med & Dent Univ, Ctr Excellence Program Frontier Res Mol Destruct, Tokyo 1138549, Japan

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 473卷 / 02期

基金：

日本学术振兴会;

关键词：

osteoimmunology; osteoclastogenesis; RANKL; NFATc1; T-H; 17;

D O I：

10.1016/j.abb.2008.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Investigation into arthritis, as well as numerous bone phenotypes found in mice lacking immune-related genes, has highlighted the importance of the interplay between the bone and immune systems, which has led to the emergence and evolution of the field of osteoimmunology. RANKL stimulates osteoclastogenesis through nuclear factor of activated T cells (NFAT) c1, which is also a crucial regulator of immunity. In rheumatoid arthritis, bone destruction is caused by the enhanced activity of osteoclasts, which is mainly dependent on interleukin-17-producing helper T cells (T(H)17). The scope of osteoimmunology has been extended to encompass a wide range of molecular and cellular interactions. The framework of osteoimmunology will provide a scientific basis for future therapeutic approaches to diseases related to both of these systems. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：166 / 171

页数：6

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