Efficient synthesis of 2,4-disubstituted thiazoles and 2-substituted 4-thiazolidinones under solvent free conditions

被引：13

作者：

Gautam, Deepika ^{[1
]}

Gautam, Poonam ^{[1
]}

Chaudhary, Ram P. ^{[1
]}

机构：

[1] St Longowal Inst Engn & Technol, Dept Chem, Longowal Sangrur 148106, Punjab, India

来源：

HETEROCYCLIC COMMUNICATIONS | 2011年 / 17卷 / 3-4期

关键词：

grinding; ionic liquid; thiazoles; thiosemicarbazones; 4-thiazolidinones; DERIVATIVES; DESIGN;

D O I：

10.1515/HC.2011.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of thiosemicarbazones 2 derived from 1-tetralones (1) with chloroacetic acid in presence of N-methylpyridinium tosylate (an ionic liquid) yields 2-substituted-4-thiazolidinones 3. The reaction of 2 with alpha-halo carbonyl compounds at room temperature under grinding conditions yields 2,4-disubstituted thiazoles 4 in excellent yields. The structures of compounds 2-4 have been established on the basis of elemental analysis, IR, NMR and mass spectral data.

引用

页码：147 / 150

页数：4

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