Improved synthesis of phytosphingosine and dihydrosphingosine from 3,4,6-tri-O-benzyl-D-galactal

被引：12

作者：

Niu, Youhong ^{[2
]}

Cao, Xiaoping ^{[2
]}

Ye, Xin-Shan ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2008年 / 91卷 / 04期

关键词：

D O I：

10.1002/hlca.200890076

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and facile synthesis of phytosphingosine and dihydrosphingosine derivatives is described with less steps and in improved overall yield (66-72%) starting from commercially available tri-O-benzyl-D-galactal. The key steps include Wittig reaction, Mitsunobu transformation, reduction, and deprotection.

引用

页码：746 / 752

页数：7

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