Expression Analysis of HIF-1α and HIF-2α Genes in Tibetan Chicken under Normoxia and Hypoxia

被引：0

作者：

Yang, Y. Z. ^{[1
]}

Bai, Y. ^{[1
]}

Dong, X. X. ^{[1
]}

Zhang, J. B. ^{[1
]}

Fang, M. ^{[1
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China

来源：

JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 2011年 / 10卷 / 16期

关键词：

Tibetan chicken; HIF-1; alpha; HIF-2; normoxia; hypoxia; adaptability; ADAPTATION; OXYGEN;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Tibetan chicken is one of those chicken breeds that could adapt to high altitude and low O(2) tension environment; it owes an integrative genetic mechanism for hypoxia adaptability compared to lowland chicken breeds. IdIF-1 alpha and HIF-2 alpha are the central factors playing important roles in maintaining organisms's oxygen homeostasis. In this study, the expression of HIF-1 alpha and HIF-2 alpha genes were investigated by Real Time-PCR in Tibetan chicken and Dwarf chicken embryo brain tissue under normoxia (21% oxygen concentration) and hypoxia (13% oxygen concentration). The results showed that Tibetan chicken always had lower mortality than Dwarf chicken during the incubation. We also detected higher HIF-alpha s expression at the late of incubation (18th day) compared with that at 12th day in all tested samples; we further obtained the expression pattern of HIP-alpha s genes in dead embryos was opposite to that in live embryos.

引用

页码：2172 / 2175

页数：4

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