Disruption of protein-protein interactions:: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

被引：54
|
作者：
Wei, Y [1 ]
McLendon, GL
Hamilton, AD
Case, MA
Purring, CB
Lin, Q
Park, HS
Lee, CS
Yu, TN
机构：
[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
[2] Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA
[3] Yale Univ, Dept Chem, New Haven, CT 06520 USA
来源：
CHEMICAL COMMUNICATIONS | 2001年 / 17期
关键词：
D O I：
10.1039/b104142h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthetic receptor I has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 +/- 1) X 10(8) M-1, and to disrupt Cc: Apaf-1 complex, a key adduct in apoptosis.
引用
收藏
页码：1580 / 1581
页数：2
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