Deficient Mismatch Repair and Lymphocytic Response to Tumor as Prognostic Markers in Stage II Colon Cancer Patients

被引：3
作者：
Sari, Murat [1 ]
Atag, Elif [1 ]
Demir, Tarik [1 ]
Simsek, Eda Tanrikulu [1 ]
Coban, Ezgi [1 ]
Cikrikcioglu, Makbule [2 ]
机构：
[1] Haydarpasa Numune Res & Training Hosp, Dept Med Oncol, Istanbul, Turkey
[2] Haydarpasa Numune Res & Training Hosp, Dept Pathol, Istanbul, Turkey
来源：
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN | 2022年 / 32卷 / 02期
关键词：
Lymphocytic response; Mismatch repair; Prognosis; Tumor-infiltrating lymphocytes; Stage II cancer; Colon cancer; MICROSATELLITE INSTABILITY; LOCATION;
D O I：
10.29271/jcpsp.2022.02.186
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To investigate the relationship between colon cancer (CC) subtypes defined by the status of tumor-infiltrating lymphocytes (TIL) and mismatch repair (MMR) combination with clinicopathological features and survival. Study Design: Observational study. Place and Duration of Study: Department of Medical Oncology, Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey, from July 2010 to March 2020. Methodology: Eighty-three patients with operated stage II colon cancer were included in the study. Pathology, surgery and oncological treatment and follow-up information were obtained from patient files; and statistical analyses were performed on overall survival (OS). Tumor-infiltrating lymphocytes and mismatch repair status was determined with the help of immunohistochemistry. Results: TIL-high and deficient MMR (dMMR) status were detected in 26 patients (31.3%) and 21 patients (25.3%), respectively. Tumors were divided into four subgroups according to TIL and MMR status. TIL-high/dMMR tumors had the most favourable prognosis, while TIL-low/proficient MMR tumors exhibited poor OS. Conclusion: The combination of TIL and MMR could enable us to differentiate patients' survival outcomes in more details. Therefore, considering that the TIL and MMR status, evaluated by IHC, may be a cost-effective and effective option for risk classification in patients with stage II colon cancer.
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收藏
页码：186 / 192
页数：7
相关论文
共 22 条
  • [1] Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer
    Andre, T.
    Shiu, K-K
    Kim, T. W.
    Jensen, B., V
    Jensen, L. H.
    Punt, C.
    Smith, D.
    Garcia-Carbonero, R.
    Benavides, M.
    Gibbs, P.
    de la Fouchardiere, C.
    Rivera, F.
    Elez, E.
    Bendell, J.
    Le, D. T.
    Yoshino, T.
    Van Cutsem, E.
    Yang, P.
    Farooqui, M. Z. H.
    Marinello, P.
    Diaz, L. A., Jr.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) : 2207 - 2218
  • [2] High-Risk Stage II Colon Cancer: Not All Risks Are Created Equal
    Babcock, Blake D.
    Aljehani, Mayada A.
    Jabo, Brice
    Choi, Audrey H.
    Morgan, John W.
    Selleck, Matthew J.
    Luca, Fabrizio
    Raskin, Elizabeth
    Reeves, Mark E.
    Garberoglio, Carlos A.
    Lum, Sharon S.
    Senthil, Maheswari
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (07) : 1980 - 1985
  • [3] Microsatellite Instability and Loss of Heterozygosity at Chromosomal Location 18q: Prospective Evaluation of Biomarkers for Stages II and III Colon Cancer-A Study of CALGB 9581 and 89803
    Bertagnolli, Monica M.
    Redston, Mark
    Compton, Carolyn C.
    Niedzwiecki, Donna
    Mayer, Robert J.
    Goldberg, Richard M.
    Colacchio, Thomas A.
    Saltz, Leonard B.
    Warren, Robert S.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (23) : 3153 - 3162
  • [4] Boland CR, 2010, GASTROENTEROLOGY, V138, P2073, DOI [10.1053/j.gastro.2010.04.024, 10.1053/j.gastro.2009.12.064]
  • [5] Clinical significance of tumor- infiltrating lymphocytes and neutrophil-to-lymphocyte ratio in patients with stage III colon cancer who underwent surgery followed by FOLFOX chemotherapy
    Cha, Yoon Jin
    Park, Eun Jung
    Baik, Seung Hyuk
    Lee, Kang Young
    Kang, Jeonghyun
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [6] Analysis of Stage and Clinical/Prognostic Factors for Colon and Rectal Cancer From SEER Registries: AJCC and Collaborative Stage Data Collection System
    Chen, Vivien W.
    Hsieh, Mei-Chin
    Charlton, Mary E.
    Ruiz, Bernardo A.
    Karlitz, Jordan
    Altekruse, Sean F.
    Ries, Lynn A. G.
    Jessup, J. Milburn
    [J]. CANCER, 2014, 120 (23) : 3793 - 3806
  • [7] Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Galon, Jerom
    Costes, Anne
    Sanchez-Cabo, Fatima
    Kirilovsky, Amos
    Mlecnik, Bernhard
    Lagorce-Pages, Christine
    Tosolini, Marie
    Camus, Matthieu
    Berger, Anne
    Wind, Philippe
    Zinzindohoue, Franck
    Bruneval, Patrick
    Cugnenc, Paul-Henri
    Trajanoski, Zlatko
    Fridman, Wolf-Herman
    Pages, Franck
    [J]. SCIENCE, 2006, 313 (5795) : 1960 - 1964
  • [8] Mismatch repair status predicts survival after adjuvant treatment in stage II colon cancer patients
    Gkekas, I.
    Novotny, J.
    Fabian, P.
    Nemecek, R.
    Palmqvist, R.
    Strigard, K.
    John, S.
    Pecen, L.
    Reginacova, K.
    Gunnarsson, U.
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 2020, 121 (02) : 392 - 401
  • [9] Deficient mismatch repair as a prognostic marker in stage II colon cancer patients
    Gkekas, Ioannis
    Novotny, Jan
    Fabian, Pavel
    Nemecek, Radim
    Palmqvist, Richard
    Strigard, Karin
    Pecen, Ladislav
    Svoboda, Tomas
    Gurlich, Robert
    Gunnarsson, Ulf
    [J]. EJSO, 2019, 45 (10): : 1854 - 1861
  • [10] Microsatellite instability as a marker of prognosis and response to therapy: A meta-analysis of colorectal cancer survival data
    Guastadisegni, Cecilia
    Colafranceschi, Mauro
    Ottini, Laura
    Dogliotti, Eugenia
    [J]. EUROPEAN JOURNAL OF CANCER, 2010, 46 (15) : 2788 - 2798
123