Carbofuran in water: Subchronic toxicity to rats

被引：21

作者：

Brkic, Dragica V. ^{[1
]}

Vitorovic, Slavoljub Lj. ^{[2
]}

Gasic, Slavica M. ^{[1
]}

Neskovic, Nesko K. ^{[1
]}

机构：

[1] Inst Pesticides & Environm Protect, Belgrade 11080, Serbia

[2] Univ Belgrade, Fac Agr, Belgrade, Serbia

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2008年 / 25卷 / 03期

关键词：

carbofuran; water; rats; toxicity;

D O I：

10.1016/j.etap.2007.11.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：334 / 341

页数：8

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