Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss

被引：144

作者：

Guelmez, Dolunay ^{[1
,2
]}

Woodford, Neil ^{[2
]}

Palepou, Marie-France I. ^{[2
]}

Mushtaq, Shazad ^{[2
]}

Metan, Gokhan ^{[1
,3
]}

Yakupogullari, Yusuf ^{[4
,5
]}

Kocagoz, Sesin ^{[6
]}

Uzun, Omrum ^{[7
]}

Hascelik, Gulsen ^{[1
]}

Livermore, David M. ^{[2
]}

机构：

[1] Hacettepe Univ, Fac Med, Dept Microbiol & Clin Microbiol, TR-06100 Ankara, Turkey

[2] Ctr Infect Hlth Protect Agcy, Antibiot Resistance Monitoring & Reference Lab, London, England

[3] Erciyes Univ, Fac Med, Dept Infect & Clin Microbiol, Kayseri, Turkey

[4] Firat Univ, Fac Med, Dept Microbiol & Clin Microbiol, TR-23169 Elazig, Turkey

[5] Malatya State Hosp, Dept Microbiol & Clin Microbiol, Malatya, Turkey

[6] Yeditepe Univ, Fac Med, Dept Microbiol & Clin Microbiol, Istanbul, Turkey

[7] Hacettepe Univ, Fac Med, Dept Internal Med, Infect Dis Sect, TR-06100 Ankara, Turkey

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2008年 / 31卷 / 06期

关键词：

Escherichia coli; Klebsiella pneumoniae; carbapenem resistance; carbapenemase; OXA-48; CTX-M ESBL;

D O I：

10.1016/j.ijantimicag.2008.01.017

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Treatment options are limited in infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, with carbapenems generally preferred. Disturbingly, however, carbapenem-resistant strains are emerging worldwide. Here we report two clinical isolates, one Escherichia coli and one Klebsiella pneumoniae, each with high-level carbapenem resistance (imipenem minimum inhibitory concentration of 32 mu g/mL). They were isolated following imipenem therapy from two hospital patients who had received imipenem therapy in different regions of Turkey. Both isolates produced OXA-48-like carbapenemases, enzymes so far reported only from Turkey. Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted. (c) 2008 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：523 / 526

页数：4

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