Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals

被引：166

作者：

Bagheri, Soghra ^{[1
]}

Squitti, Rosanna ^{[2
]}

Haertle, Thomas ^{[3
,4
,5
]}

Siotto, Mariacristina ^{[6
]}

Saboury, Ali A. ^{[3
]}

机构：

[1] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran

[2] IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy

[3] Univ Tehran, Inst Biochem & Biophys, Tehran, Iran

[4] INRA, UR Biopolymeres Interact Assemblages 1268, Equipe Fonct & Interact Prot, Nantes, France

[5] Poznan Univ Life Sci, Dept Anim Nutr & Feed Management, Poznan, Poland

[6] Fdn Don Carlo Gnocchi Onlus, Milan, Italy

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2018年 / 9卷

关键词：

Alzheimer's disease; copper; zinc; neurodegenerative disorder; amyloid plaques; cholesterol; calcium; AMYLOID-PRECURSOR-PROTEIN; LONG-TERM POTENTIATION; ABANDONING THERAPEUTIC CHELATION; ADENOSINE-DEAMINASE INHIBITORS; DITYROSINE CROSS-LINKING; NON-CERULOPLASMIN COPPER; TRANSGENIC MOUSE MODEL; SENILE PLAQUE CORES; A-BETA; OXIDATIVE STRESS;

D O I：

10.3389/fnagi.2017.00446

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid plaques in patients' brain tissue. The plaques are mainly made of beta-amyloid peptides and trace elements including Zn2+, Cu2+, and Fe2+. Some studies have shown that AD can be considered a type of metal dyshomeostasis. Among metal ions involved in plaques, numerous studies have focused on copper ions, which seem to be one of the main cationic elements in plaque formation. The involvement of copper in AD is controversial, as some studies show a copper deficiency in AD, and consequently a need to enhance copper levels, while other data point to copper overload and therefore a need to reduce copper levels. In this paper, the role of copper ions in AD and some contradictory reports are reviewed and discussed.

引用

页数：15

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