Anti-VEGF reduces inflammatory features in macular edema secondary to retinal vein occlusion

被引：12

作者：

Qin, Hai-Feng ^{[1
,2
]}

Shi, Fan-Jun ^{[2
]}

Zhang, Chao-Yang ^{[3
,4
,5
,6
,7
]}

Luo, Da-Wei ^{[3
,4
,5
,6
,7
]}

Qin, Shi-Yue ^{[2
]}

Wu, Jing ^{[8
,9
]}

Xie, Hai ^{[8
,9
]}

Zhang, Jing-Ting ^{[3
,4
,5
,6
,7
]}

Qiu, Qing-Hua ^{[3
,4
,5
,6
,7
,10
]}

Liu, Kun ^{[3
,4
,5
,6
,7
]}

Xu, Guo-Tong ^{[8
,9
]}

Xu, Guo-Xu ^{[2
]}

Zhang, Jing-Fa ^{[3
,4
,5
,6
,7
]}

机构：

[1] Changhai Hosp, Dept Ophthalmol, Shanghai 200433, Peoples R China

[2] Soochow Univ, Affiliated Hosp 2, Dept Ophthalmol, 1055 Sanxiang Rd,Outpatient Bldg,4th Floor, Suzhou 215004, Jiangsu, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Shanghai Gen Hosp, Dept Ophthalmol, 100 Haining Rd, Shanghai 200080, Peoples R China

[4] Natl Clin Res Ctr Eye Dis, Shanghai 200080, Peoples R China

[5] Shanghai Key Lab Ocular Fundus Dis, Shanghai 200080, Peoples R China

[6] Shanghai Engn Ctr Visual Sci & Photomed, Shanghai 200080, Peoples R China

[7] Shanghai Engn Ctr Precise Diag & Treatment Eye Di, Shanghai 200080, Peoples R China

[8] Tongji Univ, Sch Med, Dept Regenerat Med, Tongji Eye Inst, Shanghai 200092, Peoples R China

[9] Tongji Univ, Sch Med, Dept Pharmacol, Shanghai 200092, Peoples R China

[10] Shigatse Peoples Hosp, Dept Ophthalmol, Shigatse City 85700, Tibet Autonomou, Peoples R China

来源：

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2022年 / 15卷 / 08期

基金：

中国国家自然科学基金;

关键词：

macular edema; retinal vein occlusion; anti-VEGF; hyperreflective foci; non-perfusion area; CYTOKINES; INSIGHTS;

D O I：

10.18240/ijo.2022.08.11

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

AIM: To investigate the anti-inflammatory effect of intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) in patients with macular edema secondary to retinal vein occlusion (RVO-ME). METHODS: Twenty-eight eyes from twenty-eight treatment-naive patients (14 males and 14 females) with RVO-ME were included in this retrospective study. The retinal vein occlusion (RVO) was comprised of both central retinal vein occlusion (CRVO, n=14) and branch retinal vein occlusion (BRVO, n=14). Intravitreal injection of anti-VEGF reagents were administered monthly for three consecutive months, in which 18 patients were injected with ranibizumab and 10 patients were injected with conbercept. All eyes were imaged with optical coherence tomography angiography (OCTA) at baseline and 1wk after monthly intravitreal anti-VEGF injection. The visual acuity (VA), central macular thickness (CMT), the number of hyperreflective foci (HRF) recognized as an inflammatory sign in OCT images, and non-perfusion area (NPA), were compared before and after anti-VEGF treatments. RESULTS: The mean interval between baseline and follow-up was 29.4 +/- 0.79 (range, 27-48) d. Compared with the baseline, the VA improved (logMAR 1.5 +/- 0.1 vs 0.8 +/- 0.1, P<0. 05) and CMT decreased (460 +/- 34.0 mu m vs 268.8 +/- 12.0 mu m, P<0.05), significantly, after anti-VEGF treatment. The number of HRF was decreased significantly (76.5 +/- 4 .8 vs 47.8 +/- 4 .3, P<0.05) after anti-VEGF treatment. CONCLUSION: Anti-VEGF therapy is effective in treating RVO-ME. The mechanisms for the decreased HRF and the reduction of NPA by anti-VEGF therapy merits further exploration.

引用

页码：1296 / 1304

页数：9

共 25 条

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