Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

被引：98
作者：
Demaria, Marco [1 ]
Desprez, Pierre Yves [1 ,2 ]
Campisi, Judith [1 ,3 ]
Velarde, Michael C. [1 ]
机构：
[1] Buck Inst Res Aging, Campisi Lab, Novato, CA 94945 USA
[2] Calif Pacific Med Ctr Res Inst, San Francisco, CA USA
[3] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2015年 / 135卷 / 07期
基金：
美国国家卫生研究院;
关键词：
DNA-DAMAGE RESPONSE; GROWTH-FACTOR-BETA; MITOCHONDRIAL-DNA; IN-VIVO; EXTRACELLULAR-MATRIX; SECRETORY PHENOTYPE; PHOTODAMAGED SKIN; HUMAN-FIBROBLASTS; LIFE-SPAN; COLLAGEN;
D O I：
10.1038/jid.2015.108
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
引用
收藏
页码：1722 / 1726
页数：5
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