Fecal Microbiota Transplantation Donor Screening Updates and Research Gaps for Solid Organ Transplant Recipients

被引：10

作者：

Mehta, Nirja ^{[1
]}

Wang, Tiffany ^{[2
]}

Friedman-Moraco, Rachel J. ^{[1
]}

Carpentieri, Cynthia ^{[1
]}

Mehta, Aneesh K. ^{[1
,4
]}

Rouphael, Nadine ^{[1
]}

Dhere, Tanvi ^{[5
]}

Larsen, Christian P. ^{[4
]}

Kraft, Colleen S. ^{[1
,3
]}

Woodworth, Michael H. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Atlanta, GA USA

[3] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Dept Surg, Div Transplantat, Atlanta, GA 30322 USA

[5] Emory Univ, Sch Med, Dept Med, Div Digest Dis, Atlanta, GA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2022年 / 60卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Clostridium difficile; fecal microbiota transplant; solid organ transplant; transplant infectious diseases; CLOSTRIDIUM-DIFFICILE INFECTION; EPSTEIN-BARR-VIRUS; STOOL SAMPLES; RECURRENT; POLYOMAVIRUS; BK; CYTOMEGALOVIRUS; OUTCOMES; COLITIS; BLOOD;

D O I：

10.1128/JCM.00161-21

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this review, we discuss stool donor screening considerations to mitigate potential risks of pathogen transmission through fecal microbiota transplant (FMT) in solid organ transplant (SOT) recipients. SOT recipients have a higher risk for Clostridioides difficile infection (CDI) and are more likely to have severe CDI. FMT has been shown to be a valuable tool in the treatment of recurrent CDI (RCDI); however, guidelines for screening for opportunistic infections transmitted through FMT are underdeveloped. We review reported adverse effects of FMT as they pertain to an immunocompromised population and discuss the current understanding and recommendations for screening found in the literature while noting gaps in research. We conclude that while FMT is being performed in the SOT population, typically with positive results, there remain many unanswered questions which may have major safety implications and warrant further study.

引用

页数：10

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