Now I know my CpGs

被引：70
作者：
Krieg, AM [1 ]
机构：
[1] Dept Vet Affairs Med Ctr, Iowa City, IA 52246 USA
[2] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA
[3] Coley Pharmaceut Corp, Wellesley, MA 02481 USA
来源：
TRENDS IN MICROBIOLOGY | 2001年 / 9卷 / 06期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0966-842X(01)02039-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The vertebrate innate immune system detects the presence of infection by the recognition of molecular patterns that are present in many pathogens but absent from host tissues. For example, lipoproteins, peptidoglycans and lipopolysaccharides are ail detected by one or m ore of th e Toll-like receptors (TLRs), which have emerged as key receptors in this innate immune function. A recent study reports that a CpG motif, an immune stimulatory sequence characteristic of bacterial but not vertebrate DNA, is also detected by the TLR system.
引用
收藏
页码：249 / 252
页数：4
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