Addition of lithioimidazoles to isocyanates followed by Pd-coupling: access to 4-substituted imidazole-2,5-dicarboxamides

被引：16

作者：

Chittiboyina, AG

Reddy, CR

Watkins, EB

Avery, MA

机构：

[1] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[2] Univ Mississippi, Dept Chem, University, MS 38677 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期

关键词：

isocyanates; lithiation; imidazoles; palladium coupling;

D O I：

10.1016/j.tetlet.2004.01.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Facile access to 4-substituted N-butyl 2,5-dicarboxamides is achieved via direct lithiation of N-butyl imidazole and subsequent quenching with isocyanates followed by Pd-catalyzed coupling reactions. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1869 / 1872

页数：4

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