Addition of lithioimidazoles to isocyanates followed by Pd-coupling: access to 4-substituted imidazole-2,5-dicarboxamides

被引：16
作者：
Chittiboyina, AG
Reddy, CR
Watkins, EB
Avery, MA
机构：
[1] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, Dept Med Chem, University, MS 38677 USA
[2] Univ Mississippi, Dept Chem, University, MS 38677 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期
关键词：
isocyanates; lithiation; imidazoles; palladium coupling;
D O I：
10.1016/j.tetlet.2004.01.020
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Facile access to 4-substituted N-butyl 2,5-dicarboxamides is achieved via direct lithiation of N-butyl imidazole and subsequent quenching with isocyanates followed by Pd-catalyzed coupling reactions. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1869 / 1872
页数：4
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