Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies

被引：80
作者：
Crespel, A
Genton, P
Berramdane, M
Coubes, P
Monicard, C
Baldy-Moulinier, M
Gelisse, P
机构：
[1] Hop Gui de Chauliac, Epilepsy Unit, F-34295 Montpellier, France
[2] Ctr St Paul H Gastaut, Marseille, France
来源：
NEUROLOGY | 2005年 / 65卷 / 05期
关键词：
D O I：
10.1212/01.wnl.0000174517.21383.36
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.
引用
收藏
页码：762 / 764
页数：3
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