Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion

被引：13

作者：

Lai, Ying ^{[1
]}

Zhao, Lin ^{[2
,3
]}

Bu, Bing ^{[4
]}

Lou, Xiaochu ^{[1
]}

Li, Dechang ^{[4
]}

Ji, Baohua ^{[4
]}

Liu, Jiankang ^{[2
,3
]}

Diao, Jiajie ^{[2
,3
]}

Shin, Yeon-Kyun ^{[1
]}

机构：

[1] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA

[2] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn, Minist Educ,Sch Life Sci & Technol, Xian 710049, Peoples R China

[3] Xi An Jiao Tong Univ, Frontier Inst Life Sci, Frontier Inst Sci & Technol FIST, Xian 710049, Peoples R China

[4] Beijing Inst Technol, Dept Appl Mech, Biomech & Biomat Lab, Beijing 100081, Peoples R China

来源：

PHYSICAL BIOLOGY | 2015年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

single molecule; membrane fusion; SNARE; IN-VITRO; TARGET MEMBRANE; VESICLE DOCKING; CHOLESTEROL; SYNAPTOTAGMIN; MECHANISM; EVENTS; STEP;

D O I：

10.1088/1478-3975/12/2/025003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid molecules, structural components of biomembranes, have been proposed for an important role in membrane fusion. Through various techniques based on a protein-reconstituted vesicle-vesicle fusion system, we investigated the influence of several lipid molecules on different stages of a yeast soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion process. Lipid compositions played a significant role in the early stages, docking and lipid mixing, while only exhibiting a minor effect on fusion pore formation and dilation phases, indicated by both small and large content mixing.

引用

页数：4

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