Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study

被引：67

作者：

Guess, BW ^{[1
]}

Scholz, MC ^{[1
]}

Strum, SB ^{[1
]}

Lam, RY ^{[1
]}

Johnson, HJ ^{[1
]}

Jennrich, RI ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA USA

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2003年 / 6卷 / 04期

关键词：

prostate-specific antigen doubling time; modified citrus pectin; spline regression;

D O I：

10.1038/sj.pcan.4500679

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This trial investigated the tolerability and effect of modified citrus pectin (Pecta-Sol(R)) in 13 men with prostate cancer and biochemical prostate-specific antigen (PSA) failure after localized treatment, that is, radical prostatectomy, radiation, or cryosurgery. A total of 13 men were evaluated for tolerability and 10 for efficacy. Changes in the prostate-specific antigen doubling time (PSADT) of the 10 men were the primary end point in the study. We found that the PSADT increased (P-value < 0.05) in seven (70%) of 10 men after taking MCP for 12 months compared to before taking NICE This study suggests that MCP may lengthen the PSADT in men with recurrent prostate cancer.

引用

页码：301 / 304

页数：4

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