The TCP4 transcription factor of Arabidopsis blocks cell division in yeast at G1 → S transition

被引：21

作者：

Aggarwal, Pooja ^{[1
]}

Padmanabhan, Bhavna ^{[1
]}

Bhat, Abhay ^{[1
]}

Sarvepalli, Kavitha ^{[1
]}

Sadhale, Parag P. ^{[1
]}

Nath, Utpal ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 410卷 / 02期

关键词：

TCP transcription factor; Arabidopsis; Cell cycle; Budding yeast; G1 -> S transition; DEPENDENT KINASE INHIBITORS; SACCHAROMYCES-CEREVISIAE; PROTEIN-KINASE; CDK INHIBITOR; DNA-BINDING; CYCLE; PHO85; GROWTH; PHOSPHORYLATION; COMPLEX;

D O I：

10.1016/j.bbrc.2011.05.132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TCP transcription factors control important aspects of plant development. Members of class I TCP proteins promote cell cycle by regulating genes directly involved in cell proliferation. In contrast, members of class II TCP proteins repress cell division. While it has been postulated that class II proteins induce differentiation signal, their exact role on cell cycle has not been studied. Here, we report that TCP4, a class II TCP protein from Arabidopsis that repress cell proliferation in developing leaves, inhibits cell division by blocking G1 -> S transition in budding yeast. Cells expressing TCP4 protein with increased transcriptional activity fail to progress beyond G1 phase. By analyzing global transcriptional status of these cells, we show that expression of a number of cell cycle genes is altered. The possible mechanism of G1 -> S arrest is discussed. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：276 / 281

页数：6

共 33 条

[1] Identification of Specific DNA Binding Residues in the TCP Family of Transcription Factors in Arabidopsis [J].