The role of suppressors of cytokine signalling in thymopoiesis and T cell activation

被引：21

作者：

Fletcher, J ^{[1
]}

Starr, R ^{[1
]}

机构：

[1] St Vincents Inst, Signal Transduct Lab, Fitzroy, Vic 3065, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 09期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

SOCS proteins; thymopoiesis; T cell activation; immune regulation;

D O I：

10.1016/j.biocel.2005.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines play an essential role in mediating interactions between cells of the immune system. Suppressors of cytokine signalling proteins act to negatively regulate these cytokine signals, thereby exerting control over the expression of cytokine responsive genes. Various lines of experimental evidence suggest that two closely related members of the this family, suppressor of cytokine signalling 1 and 3, are, important in the processes of T cell development, activation and homeostasis. This review outlines the principles underlying these processes and relates these to the potentially important roles played by suppressor of cytokine signalling 1 and 3. Crown Copyright (C) 2005 Published by Elsevier Ltd. All rights reserved.

引用

页码：1774 / 1786

页数：13

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