Diagnosis and Therapy of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a biologically complex and molecularly and clinically heterogeneous disease, and its incidence is increasing as the population ages. Cytogenetic anomalies and mutation testing remain important prognostic tools for tailoring treatment after induction therapy. Despite major advances in understanding the genetic landscape of AML and its impact on the pathophysiology and biology of the disease, as well as the rapid development of new drugs, standard treatment options have not experienced major changes during the past three decades. Allogeneic hematopoietic stem cell transplantation (HSCT) remains the best chance for cure. Here we review diagnosis and therapy of AML.