Phosphine-catalyzed [3+2] cycloaddition of phthalazinium dicyanomethanides with allenoates: highly efficient synthesis of 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives

被引：11

作者：

Yuan, Chunhao ^{[1
]}

Zhou, Leijie ^{[1
]}

Sun, Zhanhu ^{[1
]}

Guo, Hongchao ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 81期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

C; N-CYCLIC AZOMETHINE IMINES; ENANTIOSELECTIVE 4+1 ANNULATIONS; ELECTRON-DEFICIENT OLEFINS; ASYMMETRIC TOTAL-SYNTHESIS; FUNCTIONALIZED TETRAHYDROPYRIDINES; CHIRAL PHOSPHINES; AMINO-ACID; ORGANIC-SYNTHESIS; FORMAL SYNTHESES; FACILE ENTRY;

D O I：

10.1039/c6ra13643e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The phosphine-catalyzed [3 + 2] cycloaddition between phthalazinium dicyanomethanides and allenoates, has been achieved in dichloromethane at room temperature, providing a broad range of novel heterocyclic compounds, 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives, as single (Z)-isomers in excellent yields (88-99% yield). All reactions are operationally simple and proceed very fast under mild reaction conditions.

引用

页码：77931 / 77936

页数：6

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