A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs

被引：18
作者：
Song, Geng-Qing [2 ]
Hou, Xiaohua [2 ]
Yang, Bin [2 ]
Sun, Yan [2 ]
Qian, Wei [2 ]
Chen, J. D. Z. [1 ]
机构：
[1] Univ Texas Galveston, Med Branch, Div Gastroenterol, Galveston, TX 77550 USA
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Div Gastroenterol, Wuhan 430022, Hubei, Peoples R China
来源：
SURGERY | 2008年 / 143卷 / 01期
关键词：
D O I：
10.1016/j.surg.2007.07.001
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background. Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses. Methods. Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying Of solids, gastric dysrhythmia, and emetic responses. Results. (1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01). Conclusions. The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a Potential for gastroparesis.
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收藏
页码：72 / 78
页数：7
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