Synthesis of Tetrahydroindole Derivatives via Metal-Free Intramolecular [4+2] Annulation of Ynamides

被引：1

作者：

Zhang Zhixin ^{[1
]}

Zhai Tongyi ^{[1
]}

Zhu Bohan ^{[2
]}

Qian Pengcheng ^{[2
]}

Ye Longwu ^{[1
,3
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China

[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Zhejiang, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 05期

基金：

中国国家自然科学基金;

关键词：

annulation reaction; metal-free catalysis; ynamides; heterocycle synthesis; DIELS-ALDER REACTION; CYCLOADDITION; CATALYST; COMPLEX; ACCESS; POWERFUL; SYSTEM; ALKYNE;

D O I：

10.6023/cjoc202201006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free reaction of 4-siloxy-3,5-diene ynamides via an intramolecular [4+2] annulation has been developed. In the presence of catalytic Et3N, this protocol leads to the facile formation of six-membered cycloadducts. This reaction can proceed smoothly under mild condition without transition-metal-catalysts and its substrate scope is wide. This strategy provides a concise and practical protocol to synthesize natural product and bioactive compounds containing 4-hydroxyl hydroindole skeletons.

引用

页码：1501 / 1508

页数：8

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