Cell cycle arrest is not senescence

被引：169
作者：
Blagosklonny, Mikhail V. [1 ]
机构：
[1] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA
来源：
AGING-US | 2011年 / 3卷 / 02期
关键词：
Cellular senescence; locked quiescence; growth stimulation; mTOR; rapamycin; gerossuppressants; GENE-EXPRESSION; GROWTH ARREST; STEM-CELLS; P53; CANCER; MTOR; QUIESCENCE; FIBROBLASTS; METABOLISM; SUPPRESSION;
D O I：
10.18632/aging.100281
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more misleadingly, with growth inhibition. With such misconceptions, cellular senescence cannot be linked to organismal aging. Also, the relation between cancer and senescence is distorted. Here I discuss why the link between arrest and senescence is semi-coincidental and how senescence is related to aging and cancer.
引用
收藏
页码：94 / 101
页数：8
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