Maintenance of heterochromatin by RNA interference of tandem repeats

被引：150

作者：

Martienssen, RA ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE GENETICS | 2003年 / 35卷 / 03期

关键词：

D O I：

10.1038/ng1252

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.

引用

页码：213 / 214

页数：2

共 18 条

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