Altered Functional Connectivity in Default Mode Network in Absence Epilepsy: A Resting-State fMRI Study

被引：213

作者：

Luo, Cheng ^{[1
]}

Li, Qifu ^{[2
,3
]}

Lai, Yongxiu ^{[1
]}

Xia, Yang ^{[1
]}

Qin, Yun ^{[1
]}

Liao, Wei ^{[1
]}

Li, Shasha ^{[2
]}

Zhou, Dong ^{[2
]}

Yao, Dezhong ^{[1
]}

Gong, Qiyong ^{[4
]}

机构：

[1] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China

[2] Sichuan Univ, Dept Neurol, W China Hosp, Chengdu 610064, Peoples R China

[3] Hainan Med Coll, Affiliated Hosp, Dept Neurol, Haikou, Peoples R China

[4] Sichuan Univ, HMRRC, Dept Radiol, W China Hosp, Chengdu 610064, Peoples R China

来源：

HUMAN BRAIN MAPPING | 2011年 / 32卷 / 03期

基金：

中国国家自然科学基金;

关键词：

fMRI; resting-state; functional connectivity; absence epilepsy; DMN; BRAIN ACTIVITY; GLOBAL SIGNAL; COGNITIVE FUNCTION; HIPPOCAMPAL DAMAGE; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; GENERALIZED SPIKE; FLUCTUATIONS; DYSFUNCTION; DISCHARGES;

D O I：

10.1002/hbm.21034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dysfunctional default mode network (DMN) has been observed in various mental disorders, including epilepsy (see review Broyd et al. [2009]: Neurosci Biobehav Rev 33:279-296). Because interictal epileptic discharges may affect DMN, resting-state fMRI was used in this study to determine DMN functional connectivity in 14 healthy controls and 12 absence epilepsy patients. To avoid interictal epileptic discharge effects, testing was performed within interictal durations when there were no interictal epileptic discharges. Cross-correlation functional connectivity analysis with seed at posterior cingulate cortex, as well as region-wise calculation in DMN, revealed decreased integration within DMN in the absence epilepsy patients. Region-wise functional connectivity among the frontal, parietal, and temporal lobe was significantly decreased in the patient group. Moreover, functional connectivity between the frontal and parietal lobe revealed a significant negative correlation with epilepsy duration. These findings indicated DMN abnormalities in patients with absence epilepsy, even during resting interictal durations without interictal epileptic discharges. Abnormal functional connectivity in absence epilepsy may reflect abnormal anatomo-functional architectural integration in DMN, as a result of cognitive mental impairment and unconsciousness during absence seizure. Hum Brain Mapp 32:438-449, 2011. (C) 2010 Wiley-Liss, Inc.

引用

页码：438 / 449

页数：12

共 69 条

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