Vernonia polyanthes as a new source of antiulcer drugs

被引：30

作者：

Barbastefano, V.

Cola, M.

Luiz-Ferreira, A.

Farias-Silva, E.

Hiruma-Lima, C. A.

Rinaldo, D.

Vilegas, W.

Souza-Brito, A. R. M.

机构：

[1] Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CEP13083-970 Campinas, SP, Cidade Universitaria Zeferino Vaz, s/n

[2] Departamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP

[3] Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista (UNESP), Araraquara, SP

来源：

FITOTERAPIA | 2007年 / 78卷 / 7-8期

基金：

巴西圣保罗研究基金会;

关键词：

Action mechanisms; Antiulcerogenic activity; Vernonia polyanthes;

D O I：

10.1016/j.fitote.2007.07.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.

引用

页码：545 / 551

页数：7