Identification of novel K-Ras G12C inhibitors using a DNA encoded library platform

被引：2
|
作者：
Arora, Shilpi [1 ]
Hupp, Chris [1 ]
Talcott, Sarah [1 ]
Narayanan, Usha [1 ]
Gikunju, Diana [1 ]
Von Rechenberg, Mortiz [1 ]
Monteiro, Michael I. [1 ]
Giulinger, John P. [1 ]
Denton, Kyle [1 ]
Clark, Matt [1 ]
Ferguson, Andrew [1 ]
McRiner, Andrew J. [1 ]
Cuozzo, John [1 ]
Huguet, Christelle [1 ]
Keefe, Anthony D. [1 ]
机构：
[1] XChem Pharmaceut, Waltham, MA USA
来源：
MOLECULAR CANCER THERAPEUTICS | 2019年 / 18卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-19-C049
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
C049
引用
收藏
页数：2
相关论文
共 50 条
  • [21] A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy
    Zhang, Ziyang
    Rohweder, Peter J.
    Ongpipattanakul, Chayanid
    Basu, Koli
    Bohn, Markus-Frederik
    Dugan, Eli J.
    Steri, Veronica
    Hann, Byron
    Shokat, Kevan M.
    Craik, Charles S.
    CANCER CELL, 2022, 40 (09) : 1060 - +
  • [22] Identification of novel covalent inhibitors of K-Ras Gl2C that are efficacious in a xenograft model of NSCLC
    Satyam, Leena Khare
    Chikkanna, Dinesh
    Aswani, K. G.
    Khairnar, Vinayak V.
    Reddy, Sreekanth
    Durgaprasad, Vakkapatla
    Radhakrishna, Kowju
    Panigrahi, Sunil K.
    Ramanathan, Anuradha
    Mahasweta, Kumari
    Lakshminarasimhan, Anirudha
    Narasimha, R. K.
    Vinutha, R.
    Gopinath, Sreevalsam
    Kumar, Suryakant
    Shah, Mubarak H.
    Ramachandra, Raghuveer
    Kiran, A. B.
    Pandit, Chetan
    Ramachandra, Murali
    CANCER RESEARCH, 2016, 76
  • [23] Novel natural inhibitors targeting KRAS G12C by computational study
    Jiang, Yuting
    Chen, Wanting
    Wang, Xinhui
    Zhou, Baolin
    Xie, Haoqun
    Hou, Yuanyuan
    Guo, Zhen
    Yu, Bo
    Zhong, Sheng
    Su, Xing
    ANTI-CANCER DRUGS, 2022, 33 (09) : 779 - 788
  • [24] Sotorasib, a selective G12C K-RAS inhibitor, modulates the tumor microenvironment to promote TNFα and IFNγ signaling and augment immunotherapy response
    Ibrahim, Mohammed L.
    Foresman, Dana
    Zheng, Hong
    Haura, Eric B.
    Abate-Daga, Daniel
    Yu, Xiaoqing
    Beg, Amer A.
    CANCER RESEARCH, 2023, 83 (07)
  • [25] 针对K-Ras(G12C)突变肿瘤的还原响应型纳米胶束的制备及评价
    卢贵茹
    刘阳
    刘晶阳
    冯友成
    马孟城
    张壮壮
    付志远
    中南药学, 2024, 22 (12) : 3156 - 3161
  • [26] Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-Ras
    Vatansever, Sezen
    Erman, Burak
    Gumus, Zeynep H.
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2020, 18 : 1000 - 1011
  • [27] Using the ResCu system for preclinical testing of KRAS G12C inhibitors
    Ruiz, Victor M.
    Hill, Lindsay
    Gadde, Manasa
    Bulow, Christopher
    Morri, Maurizio
    Goldner, Nicholas
    MOLECULAR CANCER RESEARCH, 2023, 21 (05)
  • [28] In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
    Hunter, John C.
    Gurbani, Deepak
    Ficarro, Scott B.
    Carrasco, Martin A.
    Lim, Sang Min
    Choi, Hwan Geun
    Xie, Ting
    Marto, Jarrod A.
    Chen, Zhe
    Gray, Nathanael S.
    Westover, Kenneth D.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (24) : 8895 - 8900
  • [29] Farnesyltransferase inhibitors show synergistic anticancer effects in combination with novel KRAS G12C inhibitors
    Timar, Jozsef
    Baranyi, Marcell
    Molnar, Eszter
    Randelovic, Ivan
    Cserepes, Mihaly
    Tovari, Jozsef
    Hegedus, Balazs
    CANCER RESEARCH, 2024, 84 (07)
  • [30] NMR 1H,13C, 15N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp
    Alok K. Sharma
    Seung-Joo Lee
    Minyun Zhou
    Alan C. Rigby
    Sharon A. Townson
    Biomolecular NMR Assignments, 2019, 13 : 227 - 231
12345