MicroRNAs and cancer

被引：332
作者：
McManus, MT [1 ]
机构：
[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2003年 / 13卷 / 04期
关键词：
microRNA; miRNA; cancer; oncogenesis; RNAi; notch; bHLH; Bic; His-1; mir-155; mir-142; mir-15; mir-16;
D O I：
10.1016/S1044-579X(03)00038-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The general basis of cancer is the loss of cell identity and inappropriate proliferation of cells. Classically, a universal paradigm in oncogenesis is the accumulation of mutations in the open reading frames of protein-encoding oncogenes and tumor suppressors. The identification of new classes of noncoding RNAs (ncRNA) important for development and cell homeostasis will likely change this current paradigm. Recent data suggests that a special class of ncRNAs called microRNAs might be involved in human disease. This review proposes a role for microRNAs in oncogenesis. (C) 2003 Published by Elsevier Science Ltd.
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收藏
页码：253 / 258
页数：6
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