Specification of tissue-resident macrophages during organogenesis

被引：633

作者：

Mass, Elvira ^{[1
]}

Ballesteros, Ivan ^{[1
]}

Farlik, Matthias ^{[2
]}

Halbritter, Florian ^{[2
]}

Guenther, Patrick ^{[3
]}

Crozet, Lucile ^{[1
,4
]}

Jacome-Galarza, Christian E. ^{[1
]}

Haendler, Kristian ^{[3
]}

Klughammer, Johanna ^{[2
]}

Kobayashi, Yasuhiro ^{[5
]}

Gomez-Perdiguero, Elisa ^{[6
,11
]}

Schultze, Joachim L. ^{[3
,7
,8
]}

Beyer, Marc ^{[3
,7
,8
]}

Bock, Christoph ^{[2
,9
,10
]}

Geissmann, Frederic ^{[1
,4
,6
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA

[2] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1090 Vienna, Austria

[3] Univ Bonn, Genom & Immunoregulat Life & Med Sci Inst, Bonn, Germany

[4] Weill Cornell Grad Sch Med Sci, New York, NY 10065 USA

[5] Matsumoto Dent Univ, Inst Oral Sci, 1780 Hiro Oka Gobara Shiojiri, Nagano 3900781, Japan

[6] Kings Coll London, Ctr Mol & Cellular Biol Inflammat, London SE1 1UL, England

[7] German Ctr Neurodegenerat Dis, Single Cell Genom & Epigen Unit, Bonn, Germany

[8] Univ Bonn, Bonn, Germany

[9] Med Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria

[10] Max Planck Inst Informat, D-66123 Saarbrucken, Germany

[11] Inst Pasteur, Macrophages & Endothelial Cells Grp, Dept Dev & Stem Cell Biol, CNRS,UMR 3738, Paris, France

来源：

SCIENCE | 2016年 / 353卷 / 6304期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

RNA-SEQ; GENE-EXPRESSION; FETAL MONOCYTES; PPAR-GAMMA; CELLS; ID3; ALIGNMENT; REVEALS; TRANSCRIPTOMES; INFLAMMATION;

D O I：

10.1126/science.aaf4238

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis, as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues.

引用

页数：12

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