Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma

被引：34
作者：
Wang, Ya-Dong [1 ,2 ]
Sun, Xue-Jun [1 ]
Yin, Jia-Jun [2 ]
Yin, Min [2 ]
Wang, Wei [2 ]
Nie, Zhe-Qun [2 ]
Xu, Jian [2 ]
机构：
[1] Xi An Jiao Tong Univ, Dept Gen Surg, Affiliated Hosp 1, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China
[2] Dalian Univ, Affiliated Zhongshan Hosp, Dept Gen Surg, Dalian 116001, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 106卷
关键词：
FEZF1-AS1; Hepatocellular carcinoma; Cell cycle; Epithelial-mesenchymal transition; JAK2/STAT3 signaling pathway; PROLIFERATION; CANCER; MIGRATION;
D O I：
10.1016/j.biopha.2018.05.116
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Long non-coding RNAs (lncRNAs) have emerged as key regulators in the development of hepatocellular carcinoma (HCC). In the present study, we explored the expression profile and biological role of lncRNA FEZF1-AS1 in HCC. We observed remarkable upregulation of FEZF1-AS1 in HCC tissues and cell lines, and high FEZF1-AS1 expression was correlated with aggressive phenotypes and poor prognosis of HCC patients. Furthermore, we found that FEZF1-AS1 knockdown markedly inhibited the proliferation of HCC cells by inducing cell cycle arrest. In addition, FEZF1-AS1 knockdown suppressed HCC tumor growth in vivo. Moreover, FEZF1-AS1 knockdown inhibited the migration and invasion of HCC cells through suppression of JAK2/STAT3 signaling-mediated epithelial-mesenchymal transition (EMT). In conclusion, the present study for the first time demonstrated that FEZF1-AS1 serves as an oncogenic lncRNA in human HCC and implicated FEZF1-AS1 as a valuable therapeutic target for HCC treatment.
引用
收藏
页码：134 / 141
页数：8
相关论文
共 20 条
[1]   Long non-coding RNA FEZF1-AS1 facilitates cell proliferation and migration in colorectal carcinoma [J].
Chen, Na ;
Guo, Dan ;
Xu, Qiong ;
Yang, Minhui ;
Wang, Dan ;
Peng, Man ;
Ding, Yanqing ;
Wang, Shuang ;
Zhou, Jun .
ONCOTARGET, 2016, 7 (10) :11271-11283
[2]   Issues and controversies of hepatocellular carcinoma-targeted therapy clinical trials in Asia: experts' opinion [J].
Chen, Pei-Jer ;
Furuse, Junji ;
Han, Kwang-Hyub ;
Hsu, Chiun ;
Lim, Ho-Yeong ;
Moon, HanLim ;
Qin, Shukui ;
Ye, Sheng-Long ;
Yeoh, Ee-Min ;
Yeo, Winnie .
LIVER INTERNATIONAL, 2010, 30 (10) :1427-1438
[3]   Macrophage-secreted IL-8 induces-epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway [J].
Fu, Xiu-Tao ;
Dai, Zhi ;
Song, Kang ;
Zhang, Zhuo-Jun ;
Zhou, Zheng-Jun ;
Zhou, Shao-Lai ;
Zhao, Yi-Ming ;
Xiao, Yong-Sheng ;
Sun, Qi-Man ;
Ding, Zhen-Bin ;
Fan, Jia .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 46 (02) :587-596
[4]   The hallmarks of cancer A long non-coding RNA point of view [J].
Gutschner, Tony ;
Diederichs, Sven .
RNA BIOLOGY, 2012, 9 (06) :703-719
[5]   LncRNA FEZF1-AS1 enhances epithelial-mesenchymal transition (EMT) through suppressing E-cadherin and regulating WNT pathway in non-small cell lung cancer (NSCLC) [J].
He, Rong ;
Zhang, Fei Hu ;
Shen, Ning .
BIOMEDICINE & PHARMACOTHERAPY, 2017, 95 :331-338
[6]  
Jin S., 2017, ONCOTARGET, V8
[7]   B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway [J].
Kang, Fu-biao ;
Wang, Ling ;
Jia, Heng-chuan ;
Li, Dong ;
Li, Hai-jun ;
Zhang, Yin-ge ;
Sun, Dian-xing .
CANCER CELL INTERNATIONAL, 2015, 15
[8]  
Kilkenny C, 2010, J GENE MED, V12, P561, DOI [10.1002/jgm.1473, 10.1111/j.1476-5381.2010.00872.x, 10.1113/jphysiol.2010.192278]
[9]   Gene regulation by the act of long non-coding RNA transcription [J].
Kornienko, Aleksandra E. ;
Guenzl, Philipp M. ;
Barlow, Denise P. ;
Pauler, Florian M. .
BMC BIOLOGY, 2013, 11
[10]   LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells [J].
Li, Baoguo ;
Mao, Rui ;
Liu, Changfu ;
Zhang, Weihao ;
Tang, Yong ;
Guo, Zhi .
LIFE SCIENCES, 2018, 197 :122-129
12